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Acknowledgements The study is supported by a Singapore EDB-IPP grant (grant number: RL2012035)

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The LAL test uses a lysate derived from the blood cells (amebocytes) of the horseshoe crab ( Limulus polyphemus ), which contains enzymes that clot in the presence of endotoxins

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These technologies potentially allow the setup of an in vitro test system, which resembles the in vivo situation as closely as possible 27

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