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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

(2024) CNS Neuroscience & Therapeutics , 30(3): e14676 Confirmed ARA-290 provides neuroprotection in a mouse MCAO cerebral ischaemia model via CR, significantly reducing neuronal apoptosis and inflammatory cytokines, equivalent to EPO neuroprotection but without erythropoietic side effects

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Another recent screening identified that H3K9 demethylation-mediated upregulation of BCAT1 and subsequent BCAA metabolic reprogramming is able to enhance the capacity for sublethal epidermal growth factor receptor (EGFR) inhibitor (TKI) resistance by producing ROS scavengers in lung cancer, which is a cancer where EGFR mutations are commonly found (Wang et al., 2019b)