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Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

Next, 10 g of sheared chromatin were incubated with 1 g of AR antibody (Cell signaling, 5153) or 1 g of normal rabbit IgG (Cell Signaling, 2729) as a negative control overnight at 4 C followed by incubation with 30 l of protein-G magnetic beads for 2 h at 4 C

The mechanism depends on the specific peptide: some enhance immune surveillance

Published preclinical work often looks at cell migration, blood-vessel signalling, fibroblast activity, epithelial barrier models, and how local tissue environments respond under controlled conditions

Other small studies on enzyme inducers such as phenobarbital, phenytoin, rifampicin, omeprazole and carbamazepine have suggested that their effect on 2E1 is not significant, and thus they are unlikely to be responsible for excessive NAPQI formation when taken concurrently with paracetamol 45, 132, 133

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