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Vitamin B12 is vital for energy, nerve function, and red blood cell production

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Since then, many small, short-term studies have reported an increased risk for biochemical vitamin B12 deficiency in patients taking metformin, with an incidence ranging from 5.6% to 36%.2-4 A large long-term study published in 2016 reaffirmed that B12 deficiency affects a small but significant proportion of patients taking metformin.5 This study analyzed data on 1,800 participants from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study who were at high risk for T2DM

doi: 10.1038/ncb3064 11 LeiGZhuangLGanB

Regulatory note: Gonadorelin was historically FDA-approved (Factrel

In addition to these conventional approaches, experimental research has produced transgenic lines that express genes for resistance to pests and pathogens (Sokolova et al., 2024), plants with tolerance to salinity or drought through the overexpression of transcription factors such as AhDOF-AI or AhNF-YC (Priyadarsini et al., 2025), and transgenic roots obtained through Agrobacterium rhizogenes that produce secondary metabolites of industrial or nutraceutical interest (Sokolova et al., 2024)