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Tashiro et al., 2000

Figure 1: Metabolism of APAP

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Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)

Selanks mechanism centers on the GABAergic system modulating the brains primary inhibitory neurotransmitter to produce anxiolytic effects without the sedation, dependence risk, or cognitive blunting associated with traditional benzodiazepine medications