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We have taken advantage of the ease with which ligand complexes can be produced in GR crystals, a property that extends to the isomorphous GRTR crystals, and have produced and analyzed crystals of GRTR complexes with glutathione, trypanothione, glutathionylspermidine and of a true catalytic intermediate, the mixed disulfide between trypanothione and the enzyme

adults received either 500 mg cocoa flavanols (including 80 mg epicatechin) daily or placebo, along with a multivitamin supplement or another placebo

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