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Acidosis could also neutralize ROS associated with radiotherapy, inhibit radiation-induced apoptosis, enhance the activity of P-glycoprotein (P-gp), and/or reduce the rate of proliferation of tumor cells (Peppicelli et al., 2017)

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TNF- impairs barrier function by increasing epithelial cell shedding and downregulating occludin expression [78, 79], whereas IFN- increases permeability by inducing STAT1-dependent TJ remodeling [80]

doi: 10.3389/fendo.2023.1326546 4 FurukawaSFujitaTShimabukuroMIwakiMYamadaYNakajimaYet al