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Crowe, B

Similarly, many non-GPCR membrane proteins also appear too small to interact with their proper ligands

doi: 10.1016/S0140-6736(11)61452-9 124

Compared with sham, active stimulation led to significant and sustained improvement on the International Cooperative Ataxia Rating Scale (Cohens d 0.8 post-treatment and 0.9 at three months), with nearly double the responder rate at follow-up