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Integrins are subject to redox dependent conformational changes resulting in alterations of their binding activity (Eble et al

To avoid over interpretation of preclinical data, we emphasize the need for rigorous reverse translation: validating mechanistic hypotheses from animal models in human biospecimens

10.1179/1351000211y.0000000015 Redox Rep

Since internal radiation therapy relies on the decay of radioactive sources within the body to generate radiation, the precision of targeting and dosage are vital to avoiding damage to normal tissues 16

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increased glucose metabolism, decreased antioxidant enzyme capacity, protein kinase C (PKC) activation, irreversible protein glycation, AGE formation and an imbalance between ROS formation and elimination resulting in oxidative stress [20]