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As with any supplement, periodic breaks (three months on, one month off) are a reasonable precautionary approach, particularly for individuals with no confirmed deficiency or elevated oxidative stress markers

Notably, multiple ECM-related genes are identified among the differentially expressed genes targeted by OGA, which may enhance cell migration and tissue reconstruction 53

10.1093/emboj/16.10.2794 EMBO J

Again, evidence is primarily animal-based, not FDA approved

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Some people can tolerate twice-daily use after their skin adjusts, but always listen to your skin and reduce frequency if you experience irritation