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278,279 Lifestyle interventions, particularly aerobic exercise, have also demonstrated benefits in enhancing mitochondrial biogenesis and function, offering a non-pharmacological approach to managing DPN (Fig

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instead, it substantially increased levels of TGF-1-induced key chondrogenic signaling molecules, such as p-Smad2/3 and p-ERK1/2, thereby promoting chondrogenesis

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The entire procedure usually takes 30-60 minutes