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Unlike deficiency states, which produce well-characterised neurological and haematological symptoms, there is no clearly defined clinical syndrome associated with B12 excess from supplementation alone

2014 Feb Tonje Holte Stea, Mohammad Azam Mansoor, Margareta Wandel, Solveig Uglem, Wenche Frlich

Conceptualization, Funding acquisition, Supervision, Writing-review & editing Acknowledgments We thank the high-field NMR facility at the Korea Basic Science Institute (KBSI, Ochang) and the GIST Advanced Institute of Instrumental Analysis (GIST, Gwangju) for allowing us to use their NMR spectrometers

These points make it quite clear why B12 shots are not the magic bullet for weight loss that many hope they will be

The aspartic acid residue is highly susceptible to dehydration, forming a cyclic imide that can then hydrolyze into either the original form or an inactive iso-aspartate analog

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