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In recent years, the microbiota-gut-brain axis (MGBA) has emerged as a burgeoning research field and has become a focal point in neuroscience, offering novel insights into the study and treatment of CNSDs

In some cases, a severe deficiency can lead to jaundice, which causes the skin and eyes to turn yellow

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Additionally, while GM signaling pathways and mechanisms involving the vagus nerve, immune system, microbial metabolites, hormones, and neurotransmitters may impact cognition either directly or indirectly through the HPA axis, their involvement might not always require the HPA axis (223)