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This is an entirely separate regulatory path from drug approval and does not imply it is safe or effective as a therapeutic agent

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The arthrocentesis cpt code covers three distinct clinical activities that can be performed alone or in combination on the same joint during one encounter: arthrocentesis (needle entry into the joint space), aspiration of synovial fluid when performed, and therapeutic injection of medication when performed

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In a similar analysis, in participants 56 years of age and older (Pfizer-BioNTech COVID-19 Vaccine = 7,960, placebo = 7,934), serious adverse events were reported by 0.8% of Pfizer-BioNTech COVID-19 Vaccine recipients and by 0.6% of placebo recipients who received at least 1 dose of Pfizer-BioNTech COVID-19 Vaccine or placebo, respectively

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