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The second pathway involves conversion by tryptophan 2,3-dioxygenase (TDO) in the liver and IDO(indoleamine 2,3-dioxygenase 1) in other tissues (brain, gastrointestinal tract, liver) into the kynurenine pathway, where approximately 90% of tryptophan is degraded [184,185,186]

Moreover, all three studies that investigated PRP treatment in NOA [58, 61, 62] were assessed as having a moderate risk of bias, which may further contribute to the inconsistency in outcomes and limit the overall strength of the evidence

As we age, stomach acid production naturally declines, which can make it harder to extract B12 from food

Alvir, Dr.P.H., and Michele D