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The enzyme injections can cause a brief stinging sensation, but a medical-grade topical numbing cream is applied beforehand to minimize any discomfort

We used a similar strategy to prepare the two peptides for NCL, as previously optimized for the synthesis of the d-Abl SH2 domain including the usage of the 3-amino-4-(methylamino)benzoic acid (MeDbz) linker and N-terminal capping strategy 34

Both nitric oxide and glutathione exert protective functions on the intestinal epithelium

As a control for mechanical effects of glutamate application by local puff, we found no inward currents following application of medium only (Extended Data Fig

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In cytosol, the folate cycle begins with dietary folate being converted into DHF, which is subsequently reduced to THF by the enzyme dihydrofolate reductase (DHFR)