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The CDH6CD3 complex showed comparable binding to CDH6 (Fig

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The spleen is usually moderately enlarged, and the liver may also be enlarged

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At the barrier level, increased apoptosis of intestinal epithelial cells [21], aberrant expression of tight junction proteins [22], and endoplasmic reticulum stress-mediated functional impairments [23] have been demonstrated to compromise the intestinal first line of defense

Prior to docking, the receptor protein was further processed in PyMOL 2.5.2 to remove residual water molecules, salt ions, and small molecules