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Am J Physiol 260:E846E851 Boonen S, Rosen C, Bouillon R et al (2002) Musculoskeletal effects of the recombinant human IGF-I/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture: a double-blind, placebo-controlled pilot study

Higher-Caution Situations Extra medical supervision is important if you: have a history of reactions to injectable vitamins/cobalamins have significant kidney or liver disease are pregnant or breastfeeding are offered a compounded MIC B12 product without clear labeling of ingredients, concentrations, and compounding source The FDAs overview of compounding helps explain why quality can vary (see Compounding and the FDA: Questions and Answers )

Relationship between plasma homocysteine and vitamin status in the Framingham study population

Avoid going outside in peak sunlight

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For an older person on vitamin B12 injections, once the blood level of vitamin B12 has normalized, the injections can be given once a month