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The maturation medium was covered with mineral oil (Nidacon, Gothenburg, Sweden), and the COCs were incubated for 24 h at 38.5 C, 5% CO 2, and maximal humidity

Because it is a protein, a large amount of ingested glutathione is broken down by the gut and eliminated before reaching the cells

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I know that tacrolimus may contribute to this

[11] In vitro permeation studies show the vehicle allows gradual partitioning of tretinoin into viable epidermis while retaining azelaic acid predominantly in follicles and niacinamide in the upper corneal layers, mirroring their desired sites of action

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