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Another randomized controlled trial showed that adding Bevacizumab to fluorouracil and leucovorin improved PFS in patients with mCRC for whom first-line irinotecan was judged inappropriate due to their poor functional status [81]

Brain Pathol 3(4):405412 Friedman LK, Pellegrini-Giampietro DE, Sperber EF et al (1994) Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study [J]

(ii) copper-induced ROS formation and the oxidative modification of low-density lipoprotein cholesterol facilitate the development of atherosclerotic plaques (El-Hajjar et al., 2022[129])

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Trimethylamine-N-Oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway