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The data indicate that targeting of the VEGFR, c-Met and AXL pathways with cabozantinib tends to improve outcomes in patients with metastatic melanoma

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In FOXO6, the absence of the nuclear export signal region of CR2 in FOXO6 will likely impede translocation to the cytoplasm, in line with FOXO6 being the more divergent of the 4 isoforms [47]