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CD and UC, the 2 types of IBDs, depend on many therapy classes including aminosalicylates, antimetabolites (i.e., azathioprine (AZA), 6 6-mercaptopurine (6MP), and immunosuppressants (corticosteroids and cyclosporine)

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114116 Both can also generate oxidant stress and LPO, which can be inhibited by lipophilic antioxidants such as vitamin E

Some data suggest that VHT and VHE may be promoted either by a pre-existing carnitine deficiency or by deficiency induced by VPA per se

Finbloom JA, Sousa F, Stevens MM, Desai TA (2020) Engineering the drug carrier biointerface to overcome biological barriers to drug delivery

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