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Identification of potential protein dithiol-disulfide substrates of mammalian Grx2

Despite increasing awareness and significant research advancements, treatment options comprise dopamine repleting, symptomatic therapies that have significantly increased quality of life and life expectancy, but no therapies that halt or reverse disease progression, which remain a great, unmet goal in PD research

Furthermore, it suppresses the inflammatory cytokine IL6 by inhibiting HuR-mediated mRNA stabilization, thereby blocking the pro-inflammatory and pro-ferroptotic IL6/STAT3 axis

Furthermore, glutathionylated residue C151 of roGFP2 reacted three to four times faster than glutathionylated residue C208, which is again the opposed reactivity as observed for the oxidation kinetics of both monothiol roGFP2 variants (Table 1)

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