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Based on mass-spectrometry data with systems chemistry analysis implicating PLA2 differences in ME/CFS donors and the known role of PLA2G6 in protecting against mitochondrial lipid peroxidation (54), we evaluated whether there was evidence of PLA2G6 loss in males from published bulk RNA-sequencing data

Moreover, ATRA activates the Nrf2-based pathway, as well as enhances skin resilience to oxidative stress by preventing Nrf2 degradation and modulating genes involved in antioxidant defense, such as SOD and CAT 181

This supports smoother skin texture and a more refined appearance, contributing to a whitening and brightening effect

The pyruvate dehydrogenase complex links glycolysis to the citric acid cycle under aerobic conditions