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Journal of Medicinal Chemistry, 62 (17), 79767997

87 An additional metabolite generated through the Kyn pathway is the essential redox cofactor nicotinamide adenine dinucleotide (NAD+), a molecule of fundamental importance for the maintenance of cellular homeostasis

In addition, lactate has been found to activate Mg 2+ release from the endoplasmic reticulum (ER) in a variety of cells, and this Mg 2+ transport mechanism is linked to the main metabolic feedback loop and mitochondrial bioenergetic function to promote mitochondrial Mg 2+ production 4 (Fig