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In the acute COVID-19 context, previous studies have demonstrated that vitamin B12 increases the flow of the sulfur amino acid pathway, favoring production of glutathione, an important antioxidant agent, in leukocytes of patients with moderate and severe COVID-19 18

Finally, as detailed clinical indications were not consistently available in the national administrative dataset, future research should employ a nested casecontrol design to enable more precise characterization of these variables

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