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Hypoxia and pH manipulation Hypoxia, an important feature of malignancies, has lately received a lot of attention since it inhibits angiogenesis, metastasis, and the ineffectiveness of other therapies, such as photodynamic therapy (PDT) and chemotherapy

Nature 447(7143):407412 Dawson MA, Foster SD, Bannister AJ, Robson SC, Hannah R, Wang X, Xhemalce B, Wood AD, Green AR, Gottgens B et al (2012) Three distinct patterns of histone H3Y41 phosphorylation mark active genes