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Yang et al., Development of mannosylated lipid nanoparticles for mRNA cancer vaccine with high antigen presentation efficiency and immunomodulatory capability

Louis, MO, USA) for the initial immunization, and booster immunizations were performed using a 1:1 mixture of 50 g of protein and incomplete Fuchs adjuvant ( Western blot Protein samples were collected from B

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The authors suggest that adequate vitamin B6 levels may avert psychological distress during emotional situations, such as grieving, by regulating serotonin levels.[47] Cardiovascular Support Elevated levels of homocysteine have been identified as an independent risk factor for coronary artery disease.[48] Independent of its place in the methylation cycle, evidence also suggests that homocysteine is in itself a toxic compound that can directly promote atherosclerosis, neuronal damage and mood disturbances.[49] Therefore, hyperhomocysteinaemia is not only a marker of reduced methylation status, but also a direct pathogenic agent

Bone marrow mesenchymal stem cell (BMSC)-derived EVs modified with an integrin -targeting peptide were found to enhance the efficacy of therapeutic regimens targeting pancreatic cancer by promoting the reprogramming of cancer-associated fibroblasts (CAFs) while inhibiting the pro-carcinogenic effects [62]

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