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Myristica fragrans (nutmeg) extract, acting through the Akt/JNKKeap1Nrf2HO-1 cascade, simultaneously reduced pro-inflammatory cytokines (TNF-, IL-1, IL-6) and oxidative stress markers (MDA, MPO), while enhancing IL-10, SOD, and GSH-Px activities (Li et al., 2025)

A mild, intermittent, or nonspecific symptom story should not automatically close off the diagnostic pathway, particularly when risk factors or clinical suspicion are present