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Berberine is a plant-derived alkaloid supplement that activates AMPK and influences glucose and lipid metabolism, classified as a food supplement in the UK rather than a licensed medicine

While B12 has very low toxicity as a water-soluble vitamin with excess typically excreted in urine, rare adverse reactions can occur

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Antibodies involved in the development of pernicious anemia and other autoimmune diseases

Ludwig T, Eggenschwiler J, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A