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Additionally, 86.8% of countries showed an increase in age-standardized YLD rates, with the largest increases observed in Taiwan (Province of China) (EAPC = 6.30, 95% CI: 5.45 to 7.16), the Peoples Republic of China (EAPC = 4.30, 95% CI: 3.49 to 5.12), and the Hashemite Kingdom of Jordan (EAPC = 4.04, 95% CI: 3.65 to 4.42)

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Disclosures: Grace Lai-Hung Wong: AstraZeneca, Gilead Sciences, GlaxoSmithKline and Janssen,: Advisor, Abbott, AbbVie, Ascletis, Bristol-Myers Squibb, Echosens, Gi: Speaking and Teaching, Gilead Sciences: Grant/Research Support, Mario Alvares-da-Silva: Nothing to Disclose, Fatima Higuera-de-la-Tijera: Nothing to Disclose, Ming-Lung Yu: Abbvie, Gilead and Roche diagnostics.: Grant/Research Support, Abbott, Abbvie, Gilead, Roche and Roche diagnostics: Consultant, Abbvie, BMS, Gilead, Roche and Roche diagnostics: Speaking and Teaching, Soo Aleman: Gilead: Speaking and Teaching, Francisco Javier Garca-Samaniego Rey: Gilead

Conclusions Ferroptosis has been discovered for 10 years, we have known many knowledge of ferroptosis, but the mechanism of ferroptosis, especially the lipid metabolism in ferroptosis, is still unclear