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In children with an established diagnosis of PA, parents will often know whether or not their childs condition is biotin-responsive

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Firstly, conduct high-throughput screening and preclinical validation of saponin-chemotherapeutic drug pairs across different tumor types, to identify optimal combinations that achieve mechanistic complementarity by targeting the inherent limitations of chemotherapeutic agents (e.g., drug resistance, off-target toxicity) and establish a standardized database for rational regimen design