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The standard body surface area scaling method, endorsed by the FDA for first-in-human dose estimates, typically divides the rodent dose by a factor of approximately 6.2 when converting from rat to human

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Avian Pathol

2 Thats the enzyme targeted by NSAIDs, which causes pain and inflammation

doi:10.1016/j.eclinm.2021.101080

Acknowledgments We would like to express our special thanks to the members of the Department of Gastroenterology at the First Affiliated Hospital of Chengdu Medical College