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Self-assessment of the skin should be taught as a less expensive method of monitoring, while ophthalmoscopic assessment should be considered on an annual basis, at least, to detect uveal melanomas

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Multiple causes of hyperpigmented lesions of the oral mucosa are known, with oral and labial melanotic macules as the most common melanotic lesions.1,2 Trauma, radiation, and medications may result in an increased production of melanin seen in melanotic macules, but the pathophysiological mechanism of this disorder is still unknown.1,2 Histologically, melanotic macula of the oral and labial mucosa is characterized by increased melanin in the basal cell layer and lamina propria

1409 - 1411, Journal articles | 2014 Sebaratnam DF