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In the treatment portion of this guideline, most statements are Options because most treatments demonstrate limited efficacy in a subset of patients that is not readily identifiable a priori

Activation of MAP Kinase Kinase Is Necessary and Sufficient for PC12 Differentiation and for Transformation of NIH 3T3 Cells

Enhances nitric oxide production, which supports endothelial and kidney function

A few report slight increases, possibly related to compensatory responses or anxiety about self-injection

In such cases, the subject still technically has PD, but the quality of life of the subject is significantly improved because the progression of symptoms is slowed, or even stopped (arrested) at an earlier stage than would be possible without administration of the HGF mimic(s), e.g

doi: 10.1001/jamaoto.2015.2381