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The natural collagen we are born with diminishes as we age (at a rate of about 1% per year)

Jeong et al., 2017)

However, theophylline is still available for use an alternative oral tablet control medication

& Babalola, O

10.1038/nature05286 76 JuhszC

Specifically, nicotine confers neuroprotection by enhancing dopamine activity and modulating reactive oxygen species (ROS), while CO exerts neuroprotective effects by regulating antioxidant responses and inhibiting apoptosis