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Protective role of PGC-1alpha in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling

Complete cessation typically results in gradual return to baseline over 4-8 weeks

Excessive collagen deposition impairs the cardiac tissue leading to myocardial fibrosis

Cardiovascular effects Oxidative stress-induced intracellular redox imbalance plays a pivotal role in the pathogenesis of various cardiometabolic risk factors (hyperlipidaemia, hypertriglyceridemia, hyperglycemia, hypertension, obesity) leading to severe cardiovascular diseases

The photoreduction of O 2 in chloroplast via photosystemI (PSI) leads to the formation of superoxide ions, which rapidly dismutate to H 2 O 2 spontaneously or by the action of superoxide dismutases (Asada, 1998

Adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) is a key regulatory protein of mitochondrial mass (117), and its activation significantly inhibits the activation and proliferation of RA-FLSs (118)