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This allows distal signals (from axon health and target connections) reaching nucleus influencing gene expression

Vitamin B12 deficiency is a recognised nutritional complication following bariatric surgery, including gastric banding (laparoscopic adjustable gastric banding, LAGB)

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The term NNMT inhibitors as used herein refers small molecule chemical entities that inhibit the enzymatic activity of NNMT, and includes the compounds of Formula I and Formula IA as well as compounds in Tables 1-3