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A.HuJ.et al (2020)

Antidepressants classified as SSRI, SNRI or TCA are most common

1 H NMR (600 MHz, D 2 O) (two isomers, A and B): 8.21 (s, 1H, H A11 ), 8.14 (d, J = 2.0 Hz, 1H, H B11 ), 4.96 (dd, J = 14.0, 2.0 Hz, 1H, H A7 ), 4.864.81 (m, 2H, H B2 ), 4.70 (s, 24H, H B2 ), 4.54 (d, J = 14.0 Hz, 1H, H A7 ), 3.723.66 (m, 1H, H B4 ), 3.633.59 (m, 1H, H A4 ), 3.563.48 (m, 3H, H A7/B7 ), 3.423.32 (m, 2H, H A7/D7 ), 2.64 (s, 3H, H A14 ), 2.222.17 (m, 2H, H B5 ), 2.172.10 (m, 1H, H A5 ), 2.082.02 (m, 1H, H A5/D6 ), 1.931.76 (m, 4H, H B6/C5 )

To create humanized cyclonals, we re-engineered the mouse anti-MBP cyclonal in two ways

Leukotriene can be transported by MRP1 and MRP2, calcein transported by MRP1, and bilirubin glucuronides are transported by MRP2 (251, 252)

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