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The immune system is critical in wound healing with immune cells promoting wound healing by secreting immunomodulatory molecules mainly cytokines, chemokines, and growth factors, facilitating cellular crosstalk and guiding tissue repair besides tackling recurring infections culminating into chronic wounds

Mechanistically, these changes appear to coincide with elevated NAD+ and activation of metabolic gene programs consistent with increased energy expenditure

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Another is in vivo confocal microscopy of fluorescent dextran (MW ~ 10 kDa) that when injected intravenously penetrated the intercellular junctions up the region of the tight junctions

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