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However, a potential clinical limitation of butyrate is that it is rapidly metabolized as an energy source thereby diminishing its availability to stabilize HIF

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During human brain evolution, CH methylation is almost absent in the fetal brain, rapidly accumulates after birth, and increases in the gene bodies of neurons in the prefrontal cortex, primarily affecting neuronal subtype differentiation during the early brain development phase (Rizzardi et al., 2019)

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