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On a broader level, protein-bound supersulfides are reduced to regenerate protein thiols, a process that is primarily mediated by the depersulfidation capability of the thioredoxin (Trx) and thioredoxin reductase (TrxR) systems [47,48]

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Simon GA, Maibach HI

A: A Bonne's Glutathione Nanowhite Complex uses three simultaneous brightening mechanisms: (1) Glutathione inhibits tyrosinase and reduces melanin at the master antioxidant level, (2) Natural Arbutin inhibits tyrosinase through a separate botanical pathway, and (3) Vitamin C (Ascorbyl Palmitate) interferes with melanin oxidation and provides direct radiance enhancement

The management of NCDs may be influenced by the interactions between antioxidants and metabolic enzymes (Table 1)