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Compounds that chelate free metal ions in a way that prevents them from generating free radicals offer promise in the treatment of neurodegenerative diseases and other chronic diseases in which metal-induced oxidative damage may play a pathogenic role (21)

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doi:10.1016/S0306-9877(03)00096-3

The cytotoxicity of these GSH conjugates depends essentially on GST and gamma-glutamyl transferases (GT), the enzymes which initiate the mercapturic acid synthesis pathway

Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells

NETs induce Fundc1 phosphorylation of endothelial cells, inhibit mitochondrial autophagy and lead to mitochondrial ROS overproduction and lipid peroxidation, thus inducing endothelial cell ferroptosis and microvascular dysfunction