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Current drug repurposing strategies for rare neurodegenerative disorders

Wu MH, Lu RY, Yu SJ, Tsai YZ, Lin YC, Bai ZY, et al

This assessment helps them recommend a safe and effective approach

B) Bar graph representing the percent correlation of treatment-induced postsynaptic spines to the glutamatergic presynaptic marker VGLUT1

Thus, the underlying vulnerabilities to both infections in this context and downstream CNS damage require further study

Once a lead compound is found, the candidate has to be assessed in the preclinical stage to establish the safety and efficacy, including information about properties such as absorption, distribution, metabolization, and excretion, as well as the best dosage and administration route, and side effects/adverse events