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Subjective and objective sleepiness increased significantly after restriction and returned to baseline after recovery

Therefore, while these preclinical findings are valuable for understanding LDHA as a target, their therapeutic readiness should not be overstated, and further research is crucial to assess their true clinical potential

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Metformin, a diabetes drug, alters the gut microbiome and increases SCFAs and bile acids that activate GLP-1, which has led to exploration of metformin in AD and PD trials for its possible MGBA benefits [278, 279]

Methods A nanogel delivery system combining GLUacacia complex in an alginate matrix was developed using ionic gelation