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Not generalizable

Glucose oxidation during glycolysis produces ROS that are generally held in check by the cell's antioxidant defenses, including superoxide dismutase (SOD), thioredoxin, glutathione peroxidase (GP), and catalase [115]

Future mechanistic investigations are required to determine whether BTK inhibitors have any other advantages that are pertinent to MS patients such as reducing oxidative stress, removing iron and promoting remyelination [58]

For instance, induction of iNOS in microglia leads to a decrease in cellular GSH level, whereas, under comparable conditions, the GSH status of astrocytes remains largely unaffected (Bolanos et al., 1994

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Retrieved February 6, 2025