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Fibroblast Growth Factor 21 Protects Other Organs Stressed by Chronic Energy Excess and Metabolic Dysfunction Pancreas By sensitizing adipose tissue and skeletal muscle to insulin, FGF21 reduces demand for insulin secretion, in turn lessening demand for energy generation by cells

& Vijayalakshmi, A

doi: 10.4049/jimmunol.0902661

Also, there was an increase in stillbirths and a decrease in neonate survival starting at 0.03 mg/kg/day (0.3 times the human 5 mg dose), while the number of viable newborns and pup body weight on postnatal Day 7 were decreased at 0.1 mg/kg/day (equivalent to the human 5 mg dose)

Furthermore, expression of TJ proteins ZO-1 (Fig

[DOI] [PubMed] [Google Scholar] 76.Blacher E, et al