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In vitro experiments demonstrated that NNMT overexpression significantly increased Sirt1 protein expression in primary hepatocytes, while NNMT knockdown led to a notable decrease in Sirt1 protein expression

Specifically, the reactions involved in the formation of oxylipins such as 5,15-DiHETE and 5,6-Ep-15S-HETE from arachidonic acid metabolism were found to have increased fluxes 44,45,46

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GAO X, QIAN M

Multiomics profiling reveals protective function of lignans against acetaminophen-induced hepatotoxicity

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