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The Increlex (mecasermin) FDA label, which covers native rhIGF-1 in pediatric severe primary IGFD, is the closest human reference and informs the contraindications below

In supervised studies with the GHRH analog tesamorelin, IGF-1 stayed within the age-normal range, and insulin-stimulated glucose uptake was preserved (Stanley et al., 2011)

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Additionally, if low libido persists despite adjustments to TRT dosage, changes in lifestyle factors, and addressing psychological factors, it may be necessary to explore other treatment options

A slow, steady injection over 5 to 10 seconds is preferable

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