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However, the main activator of S473 kinase is thought to be mTORC2, since inactivation of mTORC2 results in a dramatic decrease in S473 phosphorylation [18, 32, 33]

Therefore, vials containing bacteriostatic water for injection should always be stored in a cool and dry place to ensure the integrity of the solution

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Schneider et al., 2006)

Additionally, esculin (1 g-1 mg) can inhibit the p38 MAPK, c-Jun N-terminal kinase (JNK) and ERK1/2 signaling pathways and reduce the TNF- and IL-6 expression levels in mouse peritoneal macrophages (102)